AP1G1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10666(AP1G1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10666(AP1G1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The AP1G1 antibody targets the gamma-1 subunit of the Adaptor Protein Complex 1 (AP-1), a heterotetrameric complex critical for intracellular vesicle trafficking and membrane transport. AP-1 facilitates the formation of clathrin-coated vesicles, mediating cargo sorting between the trans-Golgi network (TGN) and endosomes. The gamma-1 subunit (AP1G1) plays a key role in binding to sorting signals on transmembrane proteins, ensuring proper localization of lysosomal enzymes and receptors. Dysregulation of AP-1 function is linked to disorders like Hermansky-Pudlak syndrome and neurodegenerative diseases.

AP1G1 antibodies are widely used in research to study protein trafficking, organelle biogenesis, and autophagy. They enable detection of AP1G1 expression via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, helping to visualize its distribution in cellular compartments. These antibodies are also employed in investigating AP-1's interaction with other trafficking machinery components or disease-associated mutations.

Developed in hosts like rabbit or mouse, AP1G1 antibodies undergo validation for specificity and sensitivity, often using knockout controls. Their applications extend to cancer research, as altered vesicular transport is implicated in tumor progression and drug resistance. By elucidating AP-1's role in cellular homeostasis, AP1G1 antibodies contribute to understanding both basic biology and pathological mechanisms.