RAB22A抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P10652(RAB22A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10652(RAB22A Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P10652(RAB22A Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

**Background of RAB22A Antibody**

RAB22A, a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking, particularly in endosomal sorting and recycling. It is implicated in diverse cellular processes, including vesicle formation, cargo transport, and autophagy. Dysregulation of RAB22A has been linked to cancer progression, where it promotes tumor invasion, metastasis, and chemoresistance by modulating pathways like EGFR recycling and TGF-β signaling. Its overexpression is observed in multiple cancers, such as breast, liver, and ovarian cancers, making it a potential therapeutic target.

RAB22A antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RAB22A protein levels in cells or tissues. Researchers also employ them to investigate RAB22A's interaction partners and its role in oncogenic processes or neurodegenerative diseases. Recent studies highlight its involvement in autophagosome-lysosome fusion and pathogen infection mechanisms, expanding its relevance in biomedical research. Developing specific and validated RAB22A antibodies remains crucial for advancing understanding of its molecular mechanisms and exploring targeted therapies.