ADRB3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P10649(ADRB3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of ADRB3 Antibody**

The β3-adrenergic receptor (ADRB3) is a G protein-coupled receptor primarily expressed in adipose tissue and vascular smooth muscle. It plays a key role in regulating lipolysis, thermogenesis, and energy expenditure by mediating catecholamine signaling. ADRB3 activation promotes fat breakdown and heat production, making it a focus in obesity and metabolic disorder research.

ADRB3 antibodies are tools designed to detect, quantify, or visualize this receptor in experimental settings. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study ADRB3 expression patterns in tissues, its regulation under physiological or pathological conditions (e.g., obesity, diabetes), and interactions with signaling molecules.

Interest in ADRB3 surged after the identification of the Trp64Arg polymorphism, a genetic variant linked to reduced receptor activity and increased susceptibility to weight gain, insulin resistance, and cardiovascular risks. Antibodies targeting ADRB3 help elucidate how such variants affect receptor function or localization. Additionally, they support drug development efforts, as ADRB3 agonists were once explored as anti-obesity therapeutics. Despite mixed clinical outcomes, ADRB3 remains a biomarker of interest in metabolic and cardiovascular research, underscoring the antibody's utility in both basic and translational studies.