PHIP抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10627(PHIP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10627(PHIP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

PHIP (pleckstrin homology domain-interacting protein), also known as DIDO1. is a nuclear protein implicated in transcriptional regulation, chromatin remodeling, and DNA damage response. It interacts with various signaling molecules, including components of the Wnt/β-catenin pathway, and plays roles in cell differentiation, apoptosis, and oncogenesis. Dysregulation of PHIP has been linked to cancers such as colorectal carcinoma, breast cancer, and melanoma, where it may act as an oncogene by promoting tumor growth and metastasis.

PHIP antibodies are essential tools for studying its biological functions and pathological roles. These antibodies enable detection of PHIP expression levels, subcellular localization, and protein-protein interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also use PHIP antibodies to explore its involvement in DNA repair mechanisms and epigenetic regulation, particularly in contexts of cellular stress or carcinogenesis.

Recent studies highlight PHIP's potential as a diagnostic biomarker or therapeutic target. For example, elevated PHIP expression correlates with poor prognosis in certain cancers, suggesting its utility in risk stratification. However, its dual roles in pro-survival and tumor-suppressive pathways warrant further investigation. PHIP antibodies thus remain critical for unraveling its complex biology and translational applications in precision medicine.