SIMC1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10624(SIMC1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10624(SIMC1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

SIMC1 (SUMO-interacting motifs containing 1), also known as C5orf34. is a protein encoded by the C5orf34 gene in humans. It contains two SUMO-interacting motifs (SIMs) that enable interactions with SUMO (Small Ubiquitin-like Modifier)-modified proteins, playing a role in SUMOylation-dependent cellular processes. SIMC1 is primarily localized in the nucleus and has been implicated in DNA damage response pathways, cell cycle regulation, and stress signaling. Studies suggest its involvement in the p53-mediated DNA repair mechanism, where it may act as a scaffold protein to facilitate interactions between SUMOylated substrates and downstream effectors.

The SIMC1 antibody is a crucial tool for detecting and studying the expression, localization, and function of the SIMC1 protein in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. Its development has enabled researchers to explore SIMC1's role in cancer biology, particularly its potential as a tumor suppressor or oncogene, depending on cellular context. Dysregulation of SIMC1 has been observed in certain cancers, with altered expression patterns correlating with disease progression or therapeutic resistance. The antibody's specificity for SIMC1 helps distinguish it from other SUMO-related proteins, aiding in mechanistic studies of SUMOylation networks. Validated applications typically include human, mouse, and rat samples, supporting cross-species research in molecular pathways involving genome stability and stress responses.