SBDS抗体—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela, HepG2, 293T cell lysates, Primary antibody: P10620(SBDS Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10620(SBDS Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10620(SBDS Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

**Background of SBDS Antibodies**

SBDS (Shwachman-Bodian-Diamond syndrome) antibodies are tools used to detect the SBDS protein, encoded by the *SBDS* gene located on chromosome 7q11. The SBDS protein plays critical roles in ribosome biogenesis, mitotic spindle stabilization, and cellular stress responses. Mutations in *SBDS* are linked to Shwachman-Diamond syndrome (SDS), a rare autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic dysfunction, and skeletal abnormalities.

SBDS antibodies are essential for studying the protein’s expression, localization, and interaction partners in both normal and disease contexts. They are widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate SBDS dysfunction in SDS pathogenesis. Additionally, these antibodies aid in exploring SBDS-associated pathways, such as ribosome assembly defects and genomic instability, which may contribute to cancer predisposition in SDS patients.

Research using SBDS antibodies has also advanced understanding of their role in non-SDS conditions, including leukemia and other ribosomopathies. By enabling precise detection of SBDS variants or altered expression levels, these antibodies serve as valuable diagnostic and research reagents, bridging gaps between molecular mechanisms and clinical manifestations in SBDS-related disorders.