DNAJB8抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cell, Mouse brain tissue, 293T cell lysates, Primary antibody: P10616(DNAJB8 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10616(DNAJB8 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10616(DNAJB8 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The DNAJB8 antibody is designed to target DNAJB8. a member of the heat shock protein 40 (Hsp40/DnaJ) family. DNAJB8 functions as a co-chaperone, assisting Hsp70 proteins in regulating protein folding, disaggregation, and degradation. Unlike other Hsp40 members, DNAJB8 is selectively expressed in specific tissues, including the testes and brain, and is implicated in cellular stress responses and proteostasis. Recent studies highlight its potential role in cancer progression, particularly in renal cell carcinoma, where it may promote tumor survival by suppressing protein aggregation and stabilizing oncogenic clients. Additionally, DNAJB8 has been linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, due to its interaction with aggregation-prone proteins like α-synuclein and tau.

The DNAJB8 antibody serves as a critical tool for studying these mechanisms. It enables detection of DNAJB8 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers utilize it to explore DNAJB8’s chaperone activity, its role in stress adaptation, and its pathological involvement in diseases. Its development also supports drug discovery efforts aimed at modulating proteostasis pathways. However, challenges remain in understanding DNAJB8’s precise regulatory networks and isoform-specific functions. Ongoing research with this antibody continues to uncover its therapeutic potential in targeting protein-misfolding disorders and cancers.