DDX24抗体—艾普蒂

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     Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: P00090(COX5B Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

DDX24 antibody targets the DEAD-box helicase 24 protein, a member of the DEAD-box RNA helicase family characterized by conserved Asp-Glu-Ala-Asp (DEAD) motifs. These proteins play essential roles in RNA metabolism, including unwinding RNA secondary structures, regulating transcription, splicing, and translation, and participating in ribosome biogenesis. DDX24 specifically localizes to the nucleolus and cytoplasm, where it contributes to rRNA processing, stress granule formation, and cellular stress responses. Studies suggest its involvement in antiviral defense, cancer progression, and neurological disorders, making it a protein of significant research interest.

Antibodies against DDX24 are widely used to investigate its expression, localization, and functional mechanisms in various biological contexts. They enable techniques such as Western blotting, immunofluorescence, immunoprecipitation, and flow cytometry. Validated antibodies are critical for distinguishing DDX24 from related DEAD-box proteins, often confirmed via knockout/knockdown controls. Commercial DDX24 antibodies are typically raised in hosts like rabbits or mice, with clonal options (monoclonal/polyclonal) available. Researchers prioritize antibodies with high specificity, sensitivity, and cross-reactivity appropriate for their model organisms. Recent applications include exploring DDX24's role in viral replication (e.g., HIV, SARS-CoV-2) and its dysregulation in cancers, highlighting its potential as a therapeutic or diagnostic target.