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  • RASGRP3抗体—艾普蒂
  • RASGRP3抗体—艾普蒂
  • RASGRP3抗体—艾普蒂

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RASGRP3抗体—艾普蒂

Rabbit Polyclonal RASGRP3 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-21

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
RASGRP3抗体
英文名称：
Rabbit Polyclonal RASGRP3 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5638 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
RASGRP3

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGRP3
WB Predicted band size78 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human RASGRP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell lysate, Primary antibody: P10585(RASGRP3 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10585(RASGRP3 Antibody) at dilution 1/85. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10585(RASGRP3 Antibody) at dilution 1/85. (Original magnification: ×200)    


           

参考文献

以下是关于RASGRP3抗体的3篇参考文献示例(基于公开信息概括，部分内容可能需结合真实文献调整)：

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1. **文献名称**: *RASGRP3 regulates neutrophil migration and activation in murine models of inflammation*

**作者**: Smith A, et al.

**摘要**: 本研究利用RASGRP3特异性抗体，揭示了RASGRP3在中性粒细胞趋化性和活性氧(ROS)产生中的关键作用。通过抗体阻断实验，证明RASGRP3通过调控Ras-MAPK信号通路影响炎症反应。

2. **文献名称**: *Development and validation of a monoclonal antibody targeting RASGRP3 for immunohistochemical analysis*

**作者**: Chen L, et al.

**摘要**: 作者开发了一种高特异性抗RASGRP3单克隆抗体，验证了其在人组织样本(如淋巴瘤和实体瘤)中的免疫组化应用，并证实RASGRP3表达与某些癌症的预后相关。

3. **文献名称**: *RASGRP3 deficiency attenuates autoimmunity in lupus-prone mice via modulating B cell signaling*

**作者**: Wang Y, et al.

**摘要**: 通过使用RASGRP3抗体进行蛋白表达分析，研究发现RASGRP3缺陷可抑制B细胞异常活化，缓解系统性红斑狼疮(SLE)模型小鼠的自身免疫症状，提示其作为治疗靶点的潜力。

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**注意**：以上为模拟摘要，实际文献需通过PubMed、Google Scholar等平台以关键词“RASGRP3 antibody”或“RASGRP3 inhibitor”检索。若需具体文献，建议查阅近年发表的RASGRP3相关功能研究或抗体开发论文。

       

背景信息

RASGRP3 (RAS Guanyl Releasing Protein 3) is a member of the RASGRP family of guanine nucleotide exchange factors (GEFs) that activate RAS signaling by promoting the exchange of GDP for GTP. Primarily expressed in immune cells, including B cells, T cells, and natural killer (NK) cells, RASGRP3 plays a critical role in regulating lymphocyte development, activation, and inflammatory responses. It interacts with downstream effectors like phospholipase C gamma (PLCγ) to modulate pathways such as MAPK/ERK, influencing cell proliferation, differentiation, and apoptosis. Dysregulation of RASGRP3 has been linked to autoimmune diseases, allergies, and cancers, including melanoma and leukemia.

RASGRP3 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect RASGRP3 in tissue samples or cell lines. Structural studies highlight its unique domains, including a catalytic CDC25-like GEF domain, a SAM (sterile alpha motif) domain, and EF-hand motifs for calcium sensing. Research using RASGRP3 antibodies has revealed its dual role in immune regulation and oncogenesis, making it a potential therapeutic target. Commercial RASGRP3 antibodies are typically validated for specificity against recombinant proteins or knockout models to ensure reliability in experimental settings.

       
RASGRP3抗体;RASGRP3;RASGRP3 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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