LRWD1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: PC-3 cell lysate, Primary antibody: P10576(LRWD1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10576(LRWD1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10576(LRWD1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

LRWD1 (Leucine-Rich Repeat and WD Repeat Domain-Containing Protein 1) is a nuclear protein implicated in chromatin organization and epigenetic regulation. It interacts with the origin recognition complex (ORC), playing a role in the establishment and maintenance of DNA replication origins, particularly in heterochromatic regions. LRWD1 is essential for stabilizing ORC binding during the G1 phase of the cell cycle, ensuring proper replication timing and genome stability. Additionally, it associates with heterochromatin protein 1 (HP1), facilitating heterochromatin formation and gene silencing, thereby influencing transcriptional regulation and chromosomal integrity.

LRWD1 antibodies are critical tools for studying its localization, expression, and molecular interactions. They are widely used in techniques like chromatin immunoprecipitation (ChIP), immunofluorescence (IF), and Western blotting to investigate LRWD1's role in replication licensing, chromatin dynamics, and epigenetic silencing. Research has highlighted LRWD1's importance in germ cell development, stem cell differentiation, and cancer biology. Dysregulation of LRWD1 is linked to genomic instability and oncogenesis, with studies suggesting its potential as a biomarker or therapeutic target in cancers like hepatocellular carcinoma.

These antibodies enable researchers to explore LRWD1's regulatory mechanisms in health and disease, advancing understanding of replication origin specification, heterochromatin maintenance, and cell cycle control.