PGM1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse skeletal muscle tissue, Mouse liver tissue lysates, Primary antibody: P10569(PGM1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10569(PGM1 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

**Background of PGM1 Antibody**

Phosphoglucomutase 1 (PGM1) is a key enzyme in glucose metabolism, catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate, a critical step in glycogenolysis and glycogenesis. PGM1 plays a vital role in energy homeostasis, linking glycogen metabolism with glycolysis and gluconeogenesis. Dysregulation of PGM1 has been implicated in metabolic disorders, including type 2 diabetes, and certain cancers, where altered glucose metabolism supports tumor growth.

PGM1 antibodies are essential tools for studying the enzyme’s expression, localization, and function in various tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PGM1 in biological samples. Research utilizing PGM1 antibodies has revealed its involvement in congenital disorders of glycosylation (CDG), particularly PGM1 deficiency, a rare autosomal recessive condition characterized by hypoglycemia, liver dysfunction, and skeletal muscle abnormalities.

Monoclonal and polyclonal PGM1 antibodies, often raised in rabbits or mice, target specific epitopes of the enzyme. Recent studies highlight PGM1’s potential as a biomarker in cancer prognosis, given its overexpression in malignancies like hepatocellular carcinoma. Additionally, PGM1 antibodies aid in elucidating mechanisms of metabolic adaptation in diseases, offering insights for therapeutic targeting. Ongoing research continues to explore PGM1’s broader roles in cellular signaling and disease pathology.