ASPSCR1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 293T cell lysates, Primary antibody: P10567(ASPSCR1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10567(ASPSCR1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

ASPSCR1 (Alveolar Soft Part Sarcoma Chromosomal Region Candidate 1), also known as TUG (Tether containing UBX domain for GLUT4), is a protein encoded by the *ASPSCR1* gene. It plays roles in intracellular vesicle trafficking, particularly in glucose transporter GLUT4 translocation in response to insulin, and interacts with the ubiquitin-proteasome system. Dysregulation of ASPSCR1 is linked to alveolar soft part sarcoma (ASPS), a rare cancer characterized by the chromosomal translocation t(X;17)(p11;q25), fusing *ASPSCR1* with the *TFE3* transcription factor gene. This fusion oncoprotein drives tumorigenesis by disrupting transcriptional regulation and cellular differentiation pathways.

ASPSCR1 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies, often raised in rabbits or mice, enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). In research, they help identify ASPSCR1-TFE3 fusion proteins in ASPS diagnostics and investigate its role in metabolic disorders linked to vesicle transport defects. Commercially available ASPSCR1 antibodies vary in specificity, requiring validation for target affinity and cross-reactivity. Their applications extend to exploring ASPSCR1's involvement in other cancers, transcriptional regulation, and cellular stress responses, underscoring its dual role as a trafficking regulator and oncogenic driver.