UIMC1抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HUVEC, LOVO, SKOV3, HepG2 cell lysates, Primary antibody: P10566(UIMC1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10566(UIMC1 Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10566(UIMC1 Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

The UIMC1 antibody targets the Ubiquitin Interaction Motif Containing 1 (UIMC1) protein, also known as RAP80 (Receptor-Associated Protein 80). UIMC1 is a key component of the DNA damage response (DDR) pathway, primarily involved in recognizing and repairing DNA double-strand breaks (DSBs). It functions as a scaffold protein that recruits repair factors to damage sites by binding to ubiquitinated histones through its ubiquitin-interacting motifs (UIMs). UIMC1 interacts with BRCA1 (Breast Cancer Type 1 Susceptibility Protein) as part of the BRCA1-A complex, which regulates homologous recombination repair (HRR) and maintains genomic stability. Dysregulation of UIMC1 has been linked to cancer progression, particularly in breast and ovarian cancers, due to its role in DDR and tumor suppression.

The UIMC1 antibody is widely used in research to study DNA repair mechanisms, cancer biology, and therapeutic responses. It enables detection of UIMC1 expression levels, localization, and post-translational modifications via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers also employ this antibody to explore UIMC1's involvement in chemoresistance, as impaired DDR pathways often correlate with treatment outcomes. Its role in modulating estrogen receptor signaling further highlights its relevance in hormone-driven cancers. By characterizing UIMC1's functions, the antibody contributes to understanding genomic instability in diseases and developing targeted therapies.