PTCD3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HepG2 cell, BGC-823 Cell, LOVO cell, A172 cell lysates, Primary antibody: P10564(PTCD3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10564(PTCD3 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10564(PTCD3 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

The PTCD3 (Pentatricopeptide Repeat Domain 3) antibody is a research tool used to detect and study the PTCD3 protein, a member of the PTCD family involved in mitochondrial RNA metabolism. PTCD3 is localized to mitochondria and contains pentatricopeptide repeats (PPRs), which facilitate interactions with RNA molecules. It plays a critical role in mitochondrial gene expression by stabilizing and processing mitochondrial RNA, particularly during ribosome biogenesis and translation. Dysregulation of PTCD3 has been linked to mitochondrial dysfunction, impacting cellular energy production and apoptosis.

PTCD3 antibodies are essential for investigating its expression, localization, and molecular interactions in diseases like cancer, neurodegenerative disorders, and metabolic syndromes. They are commonly used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Studies utilizing these antibodies have revealed PTCD3's role in tumor progression, where its overexpression may promote cell survival, and in neurological conditions tied to mitochondrial defects.

The development and validation of PTCD3 antibodies contribute to understanding mitochondrial biology and disease mechanisms, aiding potential therapeutic discoveries. Researchers prioritize antibodies with high specificity to avoid cross-reactivity with other PPR-containing proteins, ensuring reliable experimental outcomes.