SCARB2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10545(SCARB2 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The SCARB2 antibody targets the scavenger receptor class B member 2 (SCARB2), also known as lysosomal integral membrane protein 2 (LIMP-2). SCARB2 is a ubiquitously expressed transmembrane protein primarily localized in lysosomal and endosomal membranes. It plays critical roles in lysosomal biogenesis, membrane trafficking, and cellular uptake of lipids, acting as a receptor for beta-glucocerebrosidase (GBA1), an enzyme whose deficiency causes Gaucher disease. SCARB2 also facilitates the cellular entry of certain enteroviruses, including EV71 and coxsackievirus A16. which are linked to hand, foot, and mouth disease.

Antibodies against SCARB2 are widely used in research to study its expression, trafficking, and interaction with viral particles or lysosomal enzymes. These antibodies enable techniques such as Western blotting, immunofluorescence, and flow cytometry to explore SCARB2's involvement in lysosomal storage disorders, neurodegenerative conditions (e.g., Parkinson’s disease), and viral pathogenesis. Additionally, SCARB2 antibodies aid in elucidating its regulatory mechanisms in lipid metabolism and membrane repair processes. Understanding SCARB2's functions through antibody-based assays provides insights into therapeutic strategies for related diseases, highlighting its dual significance in cellular homeostasis and infectious disease pathways.