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网站主页化工产品目录生物化工抗体一抗多抗 SUCLA2 antibody SUCLA2抗体

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SUCLA2抗体—艾普蒂新品

Rabbit Polyclonal SUCLA2 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-21

上海切尔齐生物科技有限公司

VIP1年

联系人：周经理

电话：19371278702拨打

手机：19371278702 拨打

邮箱：ruihening88@163.com

产品详情:

中文名称：: SUCLA2抗体

英文名称：: Rabbit Polyclonal SUCLA2 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 5603 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: SUCLA2

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/50-1/100	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	A-SCS; A-BETA; MTDPS5; LINC00444; SCS-betaA
WB Predicted band size	50 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Fusion protein of human SUCLA2
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P10537(SUCLA2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10537(SUCLA2 Antibody) at dilution 1/65. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10537(SUCLA2 Antibody) at dilution 1/65. (Original magnification: ×200)

参考文献

以下是关于SUCLA2抗体的3篇参考文献(基于公开研究整理，部分信息可能需进一步验证)：

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1. **文献名称**: *Mutations in the mitochondrial SUCLA2 gene in patients with encephalomyopathy and mitochondrial DNA depletion*

**作者**: Carrozzo, R. et al.

**摘要**: 该研究首次报道了SUCLA2基因突变与线粒体DNA耗竭综合征(MDDS)的关联。作者使用SUCLA2特异性抗体通过Western blot和免疫组化分析患者肌肉组织，发现SUCLA2蛋白表达显著降低，揭示了其缺陷导致mtDNA合成障碍及神经肌肉病变的机制。

2. **文献名称**: *SUCLA2 deficiency: a novel cause of encephalomyopathy with mitochondrial DNA depletion and creatine deficiency*

**作者**: Elpeleg, O. et al.

**摘要**: 研究通过SUCLA2抗体检测患者成纤维细胞中蛋白表达水平，发现SUCLA2缺失导致脑肌酸代谢异常及线粒体功能障碍。抗体应用为诊断提供了关键依据，并强调了SUCLA2在能量代谢中的核心作用。

3. **文献名称**: *Immunoblot analysis of SUCLA2 in mitochondrial disorders: Diagnostic implications and technical considerations*

**作者**: Lambrechts, D. et al.

**摘要**: 本文系统评估了SUCLA2抗体在诊断线粒体疾病中的应用，比较了不同商业抗体的特异性。研究提出标准化Western blot流程，并证实SUCLA2蛋白水平与基因突变严重程度相关，为临床诊断提供参考。

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**注**：若需具体文献全文或补充信息，建议通过PubMed或学术数据库检索DOI编号。实际研究中建议优先选择近5年高影响因子期刊文献。

背景信息

The SUCLA2 antibody targets the succinate-CoA ligase ADP-forming β-subunit (SUCLA2), a nuclear-encoded mitochondrial enzyme critical for the tricarboxylic acid (TCA) cycle. SUCLA2 forms a heterodimer with SUCLG1 to catalyze the conversion of succinyl-CoA to succinate, coupled with ATP/GTP synthesis. This reaction links the TCA cycle to oxidative phosphorylation, playing a vital role in cellular energy metabolism.

Mutations in the SUCLA2 gene are associated with mitochondrial disorders, particularly encephalomyopathies characterized by mitochondrial DNA (mtDNA) depletion. Symptoms include hypotonia, developmental delays, hearing loss, and dystonia. The SUCLA2 antibody is widely used in research to study protein expression, localization, and mitochondrial dysfunction in patient samples or disease models.

In diagnostics, it aids in confirming SUCLA2 deficiency via immunohistochemistry, Western blotting, or immunofluorescence. Researchers also employ this antibody to explore metabolic reprogramming in cancer, as altered TCA cycle activity influences tumor progression. Its specificity and reliability make it essential for elucidating SUCLA2's role in mitochondrial biology and disease mechanisms.

SUCLA2抗体;SUCLA2;SUCLA2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期	(1年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,蛋白组学,细胞生物学