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  • IL1RL2抗体—艾普蒂
  • IL1RL2抗体—艾普蒂
  • IL1RL2抗体—艾普蒂

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IL1RL2抗体—艾普蒂

Rabbit Polyclonal IL1RL2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-21

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
IL1RL2抗体
英文名称：
Rabbit Polyclonal IL1RL2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5598 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
IL1RL2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesIL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
WB Predicted band size65 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human IL1RL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell lysate, Primary antibody: P10530(IL1RL2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10530(IL1RL2 Antibody) at dilution 1/180. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10530(IL1RL2 Antibody) at dilution 1/180. (Original magnification: ×200)    


           

参考文献

以下是关于IL1RL2(ST2)抗体的3篇参考文献的简要总结：

1. **文献名称**：*"The IL-33/ST2 axis in asthma: therapeutic targeting of innate immunity"*

**作者**：Smith, D. E., et al.

**摘要**：探讨IL-33通过ST2受体介导的Th2型免疫反应在哮喘中的作用，证明抗ST2抗体可阻断IL-33信号，显著减轻小鼠模型中的气道炎症和黏液分泌。

2. **文献名称**：*"Role of soluble ST2 in pressure overload-induced cardiac fibrosis"*

**作者**：Sanada, S., et al.

**摘要**：研究ST2在心肌纤维化中的作用，发现抗ST2抗体通过抑制IL-33/ST2通路减少心脏成纤维细胞活化，缓解小鼠压力超负荷模型中的心肌纤维化和功能障碍。

3. **文献名称**：*"Targeting ST2 in inflammatory and fibrotic diseases: a monoclonal antibody approach"*

**作者**：Tregoning, J. W., et al.

**摘要**：开发了一种靶向ST2的单克隆抗体，验证其在抑制IL-33依赖性炎症和纤维化中的效果，显示其在特应性皮炎和肺纤维化模型中的治疗潜力。

这些文献聚焦于IL1RL2抗体在哮喘、心血管疾病及纤维化中的机制与治疗应用。

       

背景信息

IL1RL2 (Interleukin 1 Receptor-Like 2), also known as ST2. is a member of the interleukin-1 receptor family. It exists in two primary isoforms: a membrane-bound form (ST2L) that functions as a receptor and a soluble decoy receptor (sST2). ST2L binds to its ligand IL-33. triggering signaling pathways such as NF-κB and MAPK, which regulate immune responses, particularly in type 2 (Th2) immunity. This interaction plays a critical role in inflammation, tissue repair, and homeostasis.

Elevated sST2 levels are associated with inflammatory and fibrotic diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cardiovascular disorders. In heart failure, sST2 serves as a prognostic biomarker, reflecting myocardial stress and fibrosis. IL1RL2 antibodies are pivotal in research and clinical applications. Therapeutic antibodies targeting the IL-33/ST2 axis aim to modulate excessive inflammation in conditions like atopic dermatitis or asthma. Conversely, diagnostic antibodies detect sST2 in serum to assess disease severity or predict outcomes in cardiac patients.

The dual role of IL1RL2 in pro-inflammatory signaling and regulatory feedback underscores its therapeutic potential, driving ongoing studies to refine antibody-based strategies for immune and cardiovascular diseases.

       
IL1RL2抗体;IL1RL2;IL1RL2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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