ERMAP抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10524(ERMAP Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

ERMAP (Erythroblast Membrane-Associated Protein) is a cell surface glycoprotein encoded by the *ERMAP* gene, primarily expressed during erythropoiesis. It plays a role in erythroblast enucleation, cell adhesion, and membrane organization, contributing to red blood cell maturation. Structurally, ERMAP contains an extracellular immunoglobulin-like domain, a transmembrane region, and a cytoplasmic tail, suggesting involvement in cell-cell or cell-matrix interactions.

ERMAP antibodies are valuable tools for studying erythroid differentiation and disorders like anemia or myelodysplastic syndromes. They enable detection of ERMAP expression in erythroblasts via techniques such as flow cytometry, immunofluorescence, or Western blot. Research also implicates ERMAP in cancer, as aberrant expression is observed in certain malignancies, potentially influencing tumor cell behavior.

Polyclonal and monoclonal ERMAP antibodies are available, often validated for specificity using knockout controls. Their applications extend to investigating ERMAP's interaction with cytoskeletal proteins or signaling pathways. Despite its established role in erythropoiesis, ERMAP's full mechanistic contributions remain under exploration, highlighting the importance of these antibodies in unraveling its physiological and pathological functions.