DNA2抗体—艾普蒂

The DNA2 antibody targets the DNA2 protein, a conserved enzyme critical in DNA replication and repair. DNA2. an ATP-dependent helicase/nuclease, facilitates processing of Okazaki fragments during lagging-strand synthesis and resolves replication fork stress by coordinating with other proteins like BLM and WRN. It plays roles in long-flap resection, Holliday junction resolution, and maintaining genomic stability. Antibodies against DNA2 are primarily research tools, enabling detection of its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using these antibodies have linked DNA2 dysfunction to replication errors, genomic instability, and diseases such as cancer, where its overexpression correlates with poor prognosis. Additionally, DNA2 variants are implicated in genetic disorders like Seckel syndrome. By elucidating DNA2's molecular mechanisms, these antibodies contribute to understanding DNA repair pathways, replication stress responses, and potential therapeutic targets. Their utility spans basic molecular biology, cancer research, and investigations into aging-related genomic decline.