DIAPH2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10521(DIAPH2 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

DIAPH2 (Diaphanous-related formin 2) is a member of the formin family of proteins, which play critical roles in cytoskeletal reorganization, cell motility, and cytokinesis. Encoded by the DIAPH2 gene located on the X chromosome (Xq21), it regulates actin polymerization through interactions with Rho GTPases, contributing to cellular processes like cell division, migration, and signal transduction. DIAPH2 is implicated in maintaining cellular architecture and has been linked to disorders such as premature ovarian insufficiency (POI) and certain cancers. Research suggests its dysregulation may influence tumor progression, particularly in hormone-related cancers like breast and prostate cancer, where altered expression correlates with metastatic potential or therapeutic resistance.

DIAPH2 antibodies are essential tools for detecting and quantifying DIAPH2 protein levels in research applications, including Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help elucidate DIAPH2's role in cellular dynamics and disease mechanisms. For instance, studies using DIAPH2 antibodies have revealed its involvement in microtubule stabilization and spindle formation during mitosis, as well as its interaction with signaling pathways like Wnt/β-catenin. Additionally, DIAPH2's X-chromosome localization has sparked interest in sex-specific disease susceptibilities. Despite its functional significance, DIAPH2's precise molecular mechanisms remain under investigation, highlighting the continued importance of reliable antibodies in advancing its biological and clinical understanding.