TTLL10抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cell lysate, Primary antibody: P10518(TTLL10 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10518(TTLL10 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

TTLL10 (tubulin tyrosine ligase-like 10) is a member of the TTLL family of enzymes involved in post-translational modifications of tubulin, particularly the addition of glutamates or glycines to microtubules. These modifications, collectively termed glutamylation or glycylation, regulate microtubule stability, dynamics, and interactions with motor proteins, influencing cellular processes like cilia formation, cell division, and intracellular transport. TTLL10 is specifically associated with the initiation of polyglutamylation, a process critical for proper ciliary function and neuronal development. Dysregulation of TTLL10 has been implicated in ciliopathies, neurodegenerative disorders, and cancer progression due to its role in microtubule network homeostasis.

Antibodies targeting TTLL10 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate TTLL10's tissue-specific distribution, overexpression in tumors, or altered activity in disease models. Recent studies highlight TTLL10's potential as a therapeutic target, particularly in cancers with aberrant microtubule dynamics. However, research on TTLL10 remains limited compared to other TTLL members, necessitating further exploration of its substrate specificity, regulatory mechanisms, and disease associations. Reliable antibodies are crucial for advancing these studies and clarifying its pathophysiological significance.