EXOG抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562, LOVO, HT-29, HUVEC cell lysates, Primary antibody: P10516(EXOG Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10516(EXOG Antibody) at dilution 1/135. (Original magnification: ×200)    

  
  

EXOG (Exonuclease G) is a mitochondrial endonuclease critical for maintaining mitochondrial genome integrity. It belongs to the ββα-Me family of metal-dependent nucleases and plays a key role in repairing oxidative DNA damage, resolving recombination intermediates, and processing RNA/DNA hybrids during mitochondrial DNA replication. Dysregulation of EXOG has been linked to mitochondrial dysfunction, which is associated with neurodegenerative disorders, aging, and cancer.

EXOG-specific antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies enable the detection of EXOG in techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the investigation of its role in mitochondrial DNA repair mechanisms and cellular responses to genotoxic stress. Studies using EXOG antibodies have revealed its dynamic expression during apoptosis and its interaction with proteins involved in mitochondrial dynamics.

Research leveraging EXOG antibodies has also explored its potential as a biomarker for diseases involving mitochondrial impairment. For instance, reduced EXOG levels correlate with neuronal degeneration, while its overexpression is observed in certain cancers, suggesting context-dependent roles. Developing high-specificity EXOG antibodies remains a priority to dissect its precise functions and therapeutic relevance in mitochondrial-related pathologies.