DIP2A抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10512(DIP2A Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10512(DIP2A Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

DIP2A (Disco-interacting protein 2 homolog A) is a conserved eukaryotic protein encoded by the *DIP2A* gene, implicated in diverse cellular processes, including neurodevelopment, epigenetic regulation, and mitochondrial function. Structurally, it contains a DNA methyltransferase-associated domain and a disco-interacting region, suggesting roles in protein-protein interactions and enzymatic activity modulation. Studies link DIP2A to neuronal differentiation, synaptic plasticity, and axonal growth, potentially through interactions with transcription factors (e.g., CREB1) or epigenetic modifiers. Dysregulation of DIP2A has been associated with neurodevelopmental disorders (autism, schizophrenia) and cancers, where it may influence cell proliferation, apoptosis, or metabolic pathways via unclear mechanisms.

DIP2A antibodies are essential tools for studying its expression patterns, subcellular localization (nuclear/cytoplasmic), and molecular interactions. Commonly used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, these antibodies often target specific epitopes within its N-terminal or C-terminal regions. However, antibody specificity remains a challenge due to DIP2A’s homology with other DIP2 family members (DIP2B/C). Validation via knockout cell lines or siRNA knockdown is recommended. Recent research also explores DIP2A’s role in mitochondrial dynamics and metabolic reprogramming, expanding its relevance in neurodegenerative and oncological contexts.