DNAJC11抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell lysate, Primary antibody: P10502(DNAJC11 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10502(DNAJC11 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10502(DNAJC11 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The DNAJC11 antibody targets a protein encoded by the *DNAJC11* gene, a member of the evolutionarily conserved DNAJ/Hsp40 family. DNAJC11 is localized to mitochondria and plays a role in mitochondrial membrane protein import, cristae morphology maintenance, and metabolic regulation. It functions as a cochaperone, interacting with HSP70 family proteins to facilitate protein folding, stability, and intracellular trafficking. Structurally, DNAJC11 contains a J-domain critical for HSP70 binding, along with transmembrane domains anchoring it to the mitochondrial inner membrane.

Research on DNAJC11 has linked it to mitochondrial dynamics, oxidative phosphorylation, and cellular stress responses. Dysregulation of DNAJC11 is implicated in mitochondrial disorders, neurodegenerative diseases, and cancer. For instance, reduced DNAJC11 expression may impair mitochondrial function, contributing to neurodegeneration, while overexpression has been observed in certain cancers, suggesting a role in tumor cell survival.

Antibodies against DNAJC11 are widely used in Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns, subcellular localization, and interactions. These tools help elucidate its physiological and pathological roles, offering insights into disease mechanisms and potential therapeutic targets. Commercial DNAJC11 antibodies are typically validated for specificity across human, mouse, and rat models, aiding comparative studies in mitochondrial biology and disease.