FARS2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and Hela cell lysates, Primary antibody: P10491(FARS2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10491(FARS2 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

The FARS2 antibody is a research tool designed to detect and study the FARS2 protein, a mitochondrial phenylalanyl-tRNA synthetase encoded by the *FARS2* gene. This enzyme plays a critical role in mitochondrial protein synthesis by catalyzing the attachment of phenylalanine to its cognate tRNA, a step essential for accurate translation of mitochondrial DNA-encoded proteins. FARS2 is localized to the mitochondrial matrix and is one of several aminoacyl-tRNA synthetases (aaRSs) crucial for maintaining mitochondrial function, particularly in energy-demanding tissues like the brain, heart, and skeletal muscle.

Mutations in *FARS2* are linked to autosomal recessive disorders, including early-onset epileptic encephalopathy, spastic paraplegia, and other mitochondrial disorders characterized by impaired oxidative phosphorylation. The FARS2 antibody is widely used in research to investigate protein expression, subcellular localization, and molecular mechanisms underlying these pathologies. It is commonly applied in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, often validated for specificity using knockout controls or siRNA-based silencing.

Studies leveraging FARS2 antibodies have advanced understanding of mitochondrial diseases, emphasizing the enzyme's role in neuronal survival and metabolic homeostasis. Researchers also explore its interaction partners and post-translational modifications to identify therapeutic targets. Commercial FARS2 antibodies are typically raised in rabbits or mice, with clonal variants (monoclonal/polyclonal) available for diverse experimental needs.