GTPBP2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10489(GTPBP2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10489(GTPBP2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The GTPBP2 antibody is a research tool used to study the function and expression of GTP-binding protein 2 (GTPBP2), a member of the Obg-like ATPase family. GTPBP2 is evolutionarily conserved and implicated in cellular processes such as RNA metabolism, translation regulation, and mitochondrial function. It interacts with ribosomal components and is thought to play a role in ribosome quality control, particularly under stress conditions. Mutations in the GTPBP2 gene have been linked to neurodevelopmental disorders, including cerebellar ataxia, and its dysfunction is associated with neurodegenerative diseases like Alzheimer’s.

Antibodies targeting GTPBP2 enable researchers to investigate its expression patterns, subcellular localization (e.g., cytosolic or mitochondrial), and interactions with other biomolecules. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing GTPBP2 antibodies have revealed its reduced expression in certain disease models, suggesting a potential role as a biomarker or therapeutic target. Ongoing research focuses on elucidating its molecular mechanisms in RNA processing, stress response, and neuronal survival. The development of specific, high-affinity GTPBP2 antibodies remains critical for advancing understanding of its pathophysiological roles.