FRMD5抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HUVEC cell, Mouse kidney tissue lysates, Primary antibody: P10488(FRMD5 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10488(FRMD5 Antibody) at dilution 1/160. (Original magnification: ×200)    

  
  

The FRMD5 (FERM domain-containing protein 5) antibody is a research tool used to detect and study the FRMD5 protein, a member of the FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain protein family. FRMD5 is implicated in regulating cell adhesion, polarity, and signaling pathways, particularly in neuronal and epithelial tissues. It interacts with membrane-associated proteins and cytoskeletal components, playing roles in maintaining cellular architecture and modulating intracellular signaling cascades, such as the Hippo pathway. Dysregulation of FRMD5 has been linked to neurological disorders and cancer progression, making it a target for studying disease mechanisms.

FRMD5 antibodies, typically monoclonal or polyclonal, are generated in hosts like rabbits or mice using immunogenic FRMD5 peptide sequences. These antibodies are validated for applications including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers employ them to investigate FRMD5 expression patterns, subcellular localization, and interactions in various tissues or disease models. Specificity is confirmed via knockdown/knockout controls. Recent studies highlight FRMD5's potential tumor-suppressive roles in cancers like glioblastoma and breast cancer, as well as its involvement in neurodevelopmental processes, driving demand for reliable antibodies to explore its functional and therapeutic relevance.