DNAJC24抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10484(DNAJC24 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10484(DNAJC24 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The DNAJC24 antibody is a research tool designed to detect and study DNAJC24. a member of the J-domain-containing protein family (Hsp40/DnaJ). DNAJC24. also known as DnaJ homolog subfamily C member 24. functions as a co-chaperone interacting with heat shock protein 70 (Hsp70) to regulate protein folding, stability, and degradation. It plays roles in cellular stress responses, protein quality control, and intracellular trafficking. While its exact biological mechanisms remain under investigation, DNAJC24 is implicated in neurodegenerative diseases, cancer, and metabolic disorders due to its association with misfolded protein accumulation and cellular stress pathways.

The antibody is typically developed in animal models (e.g., rabbit, mouse) using immunogenic peptides corresponding to specific DNAJC24 epitopes. It enables techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze DNAJC24 expression, localization, and interactions in cells or tissues. Researchers utilize this antibody to explore DNAJC24's involvement in disease pathogenesis, its regulatory networks, and potential therapeutic targets. Validation includes testing for specificity (e.g., knockout cell lines) and cross-reactivity. Commercial antibodies often provide data on applications, species reactivity, and recommended dilutions. Continued studies aim to clarify DNAJC24's physiological roles and its utility as a biomarker or drug target.