KATNA1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10483(KATNA1 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

**Background of KATNA1 Antibody**

KATNA1 (katanin p60 ATPase-containing subunit A1) is a critical subunit of the katanin complex, an ATPase responsible for severing microtubules, a process essential for cellular processes like mitosis, neuronal development, and cytoskeletal remodeling. The katanin complex, composed of the catalytic p60 subunit (KATNA1) and a regulatory p80 subunit (KATNB1), regulates microtubule dynamics by generating internal breaks, enabling rapid reorganization of microtubule networks during cell division or differentiation.

KATNA1 antibodies are tools used to detect and study the expression, localization, and function of the KATNA1 protein in various biological contexts. These antibodies have been instrumental in research exploring microtubule-related mechanisms in cancer (e.g., mitotic defects), neurodevelopmental disorders, and neurodegenerative diseases. Studies using KATNA1 antibodies have revealed its role in neuronal migration, axon growth, and spindle formation, as well as its interaction with proteins like tubulin, MEI1. and components of the ubiquitin-proteasome system.

Commercial KATNA1 antibodies are typically raised in hosts like rabbits or mice, validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers utilize these antibodies to investigate KATNA1 dysregulation linked to pathologies, including microcephaly, intellectual disability, and certain cancers. Recent work also explores its involvement in cilia formation and response to cellular stress, highlighting its broad functional relevance. Proper validation via knockout controls or siRNA is critical to ensure antibody specificity in experimental models.