GEMIN6抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10472(GEMIN6 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

The GEMIN6 antibody is a tool used to study the GEMIN6 protein, a key component of the survival of motor neuron (SMN) complex. This complex is critical for the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing. GEMIN6. along with other GEMIN proteins, stabilizes the SMN complex and facilitates its role in assembling snRNPs. Mutations in SMN complex components, including SMN1. are linked to spinal muscular atrophy (SMA), a genetic disorder causing motor neuron degeneration.

Researchers use GEMIN6 antibodies to investigate SMN complex assembly, snRNP synthesis, and mRNA splicing mechanisms, particularly in the context of SMA pathogenesis. These antibodies are employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect GEMIN6 expression, localization, and interactions in cellular or tissue samples. They also help evaluate SMN complex integrity in disease models or therapeutic studies targeting SMA.

GEMIN6 antibodies are typically raised in rabbits or mice and may vary in clonality (monoclonal/polyclonal) and species reactivity (human, mouse, rat). Their applications extend to both basic research on RNA processing and translational studies aiming to modulate SMN complex activity. By enabling precise analysis of GEMIN6 dynamics, these antibodies contribute to understanding cellular splicing machinery and developing SMA biomarkers or therapies.