FABP6抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse small intestines tissue lysate, Primary antibody: P10470(FABP6 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10470(FABP6 Antibody) at dilution 1/200. (Original magnification: ×200)    

  
  

**Background of FABP6 Antibody**

Fatty acid-binding protein 6 (FABP6), also known as ileal bile acid-binding protein (I-BABP), is a cytoplasmic protein primarily expressed in the distal ileum. It belongs to the FABP family, which facilitates the intracellular transport and metabolism of lipids, including bile acids. FABP6 plays a critical role in the enterohepatic circulation of bile acids by binding to bile salts in the ileum, aiding their absorption and transport to the liver. This process is essential for maintaining cholesterol homeostasis, lipid digestion, and signaling pathways regulated by bile acids.

FABP6 antibodies are essential tools for studying the expression, localization, and function of FABP6 in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate FABP6’s role in intestinal diseases, metabolic disorders, and cancers. Dysregulation of FABP6 has been linked to colorectal cancer, gallstone formation, and inflammatory bowel diseases (IBD), making it a potential biomarker or therapeutic target.

These antibodies are typically raised against specific epitopes of human or murine FABP6. ensuring species-specific reactivity. Validation includes testing for cross-reactivity with other FABP family members (e.g., FABP1. FABP2) to confirm specificity. Commercial FABP6 antibodies are available in monoclonal or polyclonal formats, catering to diverse research needs. Ongoing studies continue to explore FABP6’s interaction with nuclear receptors (e.g., FXR) and its impact on lipid metabolism, highlighting its significance in both basic and clinical research.