EML1抗体—艾普蒂

EML1 (Echinoderm Microtubule-Associated Protein-Like 1) is a microtubule-binding protein belonging to the conserved EML family, which regulates microtubule dynamics, cell division, and intracellular transport. It is highly expressed in the brain, particularly during neurodevelopment, and plays a role in neuronal migration and cortical layering. EML1 antibodies are essential tools for studying its expression, localization, and function in cellular and tissue contexts. Research has linked EML1 mutations or dysregulation to neurodevelopmental disorders, such as cortical malformations (e.g., subcortical band heterotopia), and certain cancers, where altered microtubule stability may drive tumor progression. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect EML1 in human, mouse, or rat samples. Recent studies also explore EML1's interaction with other microtubule-associated proteins and its potential as a therapeutic target or biomarker. However, variability in antibody specificity across isoforms (due to alternative splicing) requires careful validation in experimental models. Overall, EML1 antibodies facilitate critical insights into neurobiology, oncology, and developmental pathways.