SLC30A3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562, Jurkat and 293T cell lysates, Primary antibody: P10425(SLC30A3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10425(SLC30A3 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10425(SLC30A3 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The SLC30A3 antibody is a crucial tool for studying the solute carrier family 30 member 3 (SLC30A3), also known as zinc transporter 3 (ZnT3). Encoded by the *SLC30A3* gene, ZnT3 facilitates zinc transport into intracellular vesicles, particularly within the brain, where it regulates synaptic zinc homeostasis. It is predominantly expressed in neurons, especially in the hippocampus and cortex, and is essential for loading zinc into synaptic vesicles. This vesicular zinc plays a role in neurotransmission, synaptic plasticity, and neuromodulation, with implications in neurological disorders such as Alzheimer's disease and epilepsy.

SLC30A3 antibodies are widely used in neuroscience research to detect ZnT3 protein expression and localization via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies help elucidate zinc's role in neuronal signaling and pathology. Commercially available antibodies are typically raised against specific epitopes of human or murine ZnT3. and validation often includes knockout controls to ensure specificity. Challenges may arise due to cross-reactivity with other SLC30 family members, emphasizing the need for rigorous validation. Research involving SLC30A3 antibodies contributes to understanding zinc metabolism, neurodegenerative mechanisms, and potential therapeutic targets.