SLC35F6抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10413(SLC35F6 Antibody) at dilution 1/95. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10413(SLC35F6 Antibody) at dilution 1/95. (Original magnification: ×200)    

  
  

The SLC35F6 antibody is a research tool designed to detect the solute carrier family 35 member F6 (SLC35F6), a protein belonging to the SLC35 family of nucleotide-sugar transporters. These transporters are primarily localized in the Golgi apparatus and endoplasmic reticulum, facilitating the translocation of nucleotide sugars required for glycosylation processes. SLC35F6 is implicated in cellular glycosylation homeostasis, though its exact substrates and physiological roles remain under investigation. Recent studies suggest its potential involvement in cancer biology, with altered expression observed in certain tumors, possibly influencing cell proliferation, metastasis, or drug resistance.

The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study SLC35F6 expression patterns across tissues or cell lines. Commercial SLC35F6 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein’s conserved regions. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm specificity. Challenges in its application may arise from cross-reactivity with other SLC family members due to structural homology.

Research utilizing this antibody contributes to elucidating SLC35F6’s role in cellular metabolism, disease mechanisms, and its potential as a biomarker or therapeutic target. However, comprehensive functional studies are still needed to fully define its biological significance.