ZNF821抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10412(ZNF821 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

The ZNF821 antibody is a research tool designed to detect and study the zinc finger protein 821 (ZNF821), a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger domains. ZNF821 is believed to function as a transcription regulator, potentially influencing gene expression by binding to DNA or interacting with other proteins. While its precise biological roles remain under investigation, preliminary studies suggest involvement in cellular processes such as differentiation, proliferation, and apoptosis. Dysregulation of ZNF821 has been tentatively linked to certain cancers and neurodegenerative disorders, though mechanistic insights are limited.

Antibodies targeting ZNF821 are typically produced using recombinant protein fragments or synthetic peptides as immunogens, yielding polyclonal or monoclonal variants. These antibodies enable researchers to investigate ZNF821's expression patterns, subcellular localization, and protein-protein interactions through techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP). Validation data often include specificity tests using knockout cell lines or siRNA-mediated knockdown controls. Commercial antibodies usually specify reactivity across human, mouse, or rat samples, with applications in both basic research and clinical studies exploring disease biomarkers. Recent studies have utilized ZNF821 antibodies to analyze its downregulation in tumor tissues and its potential role in modulating stress response pathways. However, variability in antibody performance across experimental conditions remains a technical consideration for researchers.