POC1A抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse placenta tissue lysate, Primary antibody: P10410(POC1A Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10410(POC1A Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The POC1A (Proteasome Assembly Chaperone 1 Homolog A) antibody is a tool used to study the POC1A protein, a conserved eukaryotic protein critical for centriole duplication, ciliogenesis, and cell cycle progression. POC1A functions as a structural component of centrioles, playing a key role in maintaining centrosome integrity and ensuring proper spindle formation during mitosis. It interacts with other centriolar proteins like SAS-6 and CEP135 to stabilize centriole architecture. Dysregulation of POC1A is linked to ciliopathies, microcephaly, and cancers, as aberrant centrosome dynamics can lead to genomic instability.

Research using POC1A antibodies has elucidated its dual role in both early centriole assembly and late-stage maturation. The antibody is widely employed in techniques such as immunofluorescence, Western blotting, and immunohistochemistry to visualize POC1A localization (primarily at centrosomes and basal bodies) and quantify expression levels. Studies in model organisms, including zebrafish and mice, have revealed its necessity for embryonic development, particularly in tissues reliant on cilia function. Recent structural analyses using POC1A-specific antibodies also contributed to understanding its interaction networks in 3D centriole models. Commercially available polyclonal or monoclonal POC1A antibodies are typically raised in rabbits or mice, validated for species cross-reactivity (human, mouse, rat), and used in both basic research and clinical investigations targeting ciliopathies or cancer biomarkers.