RBM4抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and HepG2 cell lysates, Primary antibody: P10409(RBM4 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

The RBM4 (RNA-binding motif protein 4) antibody is a tool used to study the RBM4 protein, a member of the RNA-binding protein family involved in post-transcriptional gene regulation. RBM4 contains RNA recognition motifs (RRMs) and a KH domain, enabling its interaction with RNA molecules to modulate splicing, translation, and stability of target transcripts. It plays critical roles in cell differentiation, apoptosis, and stress responses, particularly in muscle development and neural functions. Dysregulation of RBM4 has been implicated in cancers, neurodegenerative diseases, and metabolic disorders.

The RBM4 antibody is widely utilized in research to detect RBM4 expression levels, localization (nucleus/cytoplasm), and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Its specificity is validated using knockout controls or siRNA-mediated depletion. Studies employing this antibody have revealed RBM4's dual role in tumorigenesis—acting as either an oncogene or tumor suppressor depending on cellular context—and its involvement in alternative splicing events linked to diseases like amyotrophic lateral sclerosis (ALS). Commercial RBM4 antibodies are typically raised against epitopes within its N-terminal or RRM regions, with validation data essential for ensuring experimental reliability.