TMOD1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P10406(TMOD1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10406(TMOD1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The TMOD1 antibody is a crucial tool in studying tropomodulin 1 (TMOD1), a cytoskeletal protein that regulates actin filament dynamics by capping their pointed ends. TMOD1 plays a vital role in maintaining the stability and length of actin filaments, particularly in erythrocytes and muscle cells, where it ensures structural integrity and functional contractility. Dysregulation of TMOD1 has been linked to various pathologies, including cardiomyopathies, muscular dystrophies, and blood disorders like hemolytic anemia.

The TMOD1 antibody is widely used in immunoassays (e.g., Western blotting, immunohistochemistry, immunofluorescence) to detect TMOD1 expression, localization, and interactions in cells and tissues. Researchers employ it to investigate TMOD1's role in cell morphology, mechanical properties, and signaling pathways. Polyclonal and monoclonal variants are available, typically generated in rabbits or mice using recombinant TMOD1 protein fragments. Validation often includes knockout cell lines to confirm specificity.

Recent studies highlight TMOD1's potential as a biomarker in cancer, where its aberrant expression correlates with tumor progression and metastasis. The antibody also aids in exploring therapeutic targets for diseases linked to actin cytoskeleton dysfunction. Its application spans cell biology, pathology, and drug development, underscoring its importance in both basic research and clinical investigations.