FCRLA抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Ramos cell lysate, Primary antibody: P10405(FCRLA Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10405(FCRLA Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10405(FCRLA Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

Fc receptor-like A (FCRLA) is an intracellular protein predominantly expressed in B lymphocytes and germinal center-associated cells. Unlike classical Fc receptors, FCRLA lacks a transmembrane domain and does not directly bind immunoglobulins. Discovered in the early 2000s, it belongs to the Fc receptor homolog (FCRH) family, encoded within the human leukocyte receptor complex. FCRLA is thought to play a regulatory role in B cell development and antibody production, potentially interacting with immunoglobulins during their assembly in the endoplasmic reticulum.

Antibodies targeting FCRLA are essential tools for studying its expression, localization, and function. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using FCRLA antibodies has linked the protein to autoimmune diseases (e.g., lupus), B cell malignancies, and immunodeficiency disorders, suggesting its involvement in immune regulation. However, the exact molecular mechanisms of FCRLA remain unclear, partly due to its unique intracellular retention and lack of direct ligand-binding activity.

FCRLA antibodies are particularly valuable in exploring its potential as a biomarker or therapeutic target in B cell-related pathologies. Their development has advanced understanding of FCRLA's role in balancing immune activation and tolerance, though further studies are needed to clarify its precise biological functions.