HAUS6抗体—艾普蒂

The HAUS6 antibody is a research tool used to detect HAUS6. a key component of the HAUS (homologous to augmin subunits) complex, which plays a critical role in mitotic spindle assembly and microtubule organization during cell division. The HAUS complex, comprising eight subunits (HAUS1-HAUS8), functions alongside the augmin complex to amplify microtubule nucleation within the spindle, ensuring proper chromosome segregation and genomic stability. HAUS6. specifically, stabilizes the HAUS complex and facilitates its interaction with other mitotic machinery, such as γ-tubulin and the γ-tubulin ring complex (γ-TuRC), to promote microtubule branching and spindle integrity. Dysregulation of HAUS6 has been linked to mitotic errors, chromosomal instability, and cancer progression. Antibodies targeting HAUS6 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its expression, localization, and interactions in cellular models. These studies help elucidate mechanisms underlying spindle defects, aneuploidy, and oncogenesis, making HAUS6 a potential biomarker or therapeutic target in cancer research.