TMOD3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P10398(TMOD3 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10398(TMOD3 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The TMOD3 antibody is a crucial tool in studying tropomodulin 3 (TMOD3), a member of the tropomodulin family involved in regulating cytoskeletal dynamics. TMOD3 binds to actin filaments and tropomyosin, stabilizing the pointed ends of actin filaments in non-muscle cells, thereby influencing cell shape, motility, and intracellular trafficking. It plays roles in diverse processes, including erythropoiesis, neuronal development, and epithelial polarity. Research on TMOD3 has linked it to pathologies such as cancer metastasis, neurodegenerative disorders, and cardiovascular diseases, highlighting its biomedical relevance.

Antibodies targeting TMOD3 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect its expression, localization, and interactions. These antibodies are typically raised in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of the human TMOD3 protein. Validation often includes testing reactivity across species (e.g., human, mouse, rat) and confirming specificity via knockout controls. Commercially available TMOD3 antibodies vary in clonality (monoclonal/polyclonal), conjugates, and applications, requiring careful selection based on experimental needs. Recent studies employing TMOD3 antibodies have shed light on its role in mechanotransduction, viral infection pathways, and metabolic regulation, underscoring its multifaceted functions in cellular homeostasis. Reliable TMOD3 antibodies remain essential for advancing mechanistic insights into its contributions to health and disease.