GMPR抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10391(GMPR Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of GMPR Antibodies**

GMPR (Guanosine Monophosphate Reductase) is an enzyme critical in purine metabolism, catalyzing the NADPH-dependent conversion of GMP to IMP, a key step in nucleotide homeostasis. Dysregulation of GMPR has been implicated in metabolic disorders, immune dysfunction, and cancer, where altered nucleotide pools affect cell proliferation and survival.

GMPR antibodies are essential tools for studying this enzyme's expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, aiding research into GMPR's role in diseases. For instance, reduced GMPR levels are linked to oxidative stress resistance in certain cancers, while polymorphisms correlate with autoimmune conditions like lupus.

These antibodies are typically developed against conserved epitopes in human GMPR (isoforms 1 and 2) and cross-react with homologs in model organisms. Recent studies also explore GMPR as a therapeutic target, with antibodies potentially guiding drug development. Challenges include ensuring specificity due to structural similarities with other oxidoreductases. Overall, GMPR antibodies bridge molecular insights and clinical applications in metabolic and oncological research.