TFAP4抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10379(TFAP4 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

**Background of TFAP4 Antibody**

The TFAP4 antibody is a tool used to detect transcription factor AP-4 (activating enhancer-binding protein 4), a member of the AP-4/Helix-Loop-Helix leucine zipper (bHLH-ZIP) family of transcription factors. Encoded by the *TFAP4* gene (located on chromosome 16q23.1 in humans), AP-4 regulates gene expression by binding to E-box-like DNA sequences (CAGCTG) and plays roles in cell cycle progression, differentiation, and oncogenesis. It is ubiquitously expressed and interacts with other proteins, such as p53. to modulate transcriptional activity.

AP-4 has garnered attention in cancer research due to its overexpression in malignancies like colorectal cancer, hepatocellular carcinoma, and neuroblastoma. It promotes tumor growth by suppressing apoptosis, enhancing cell proliferation, and driving epithelial-mesenchymal transition (EMT). Additionally, AP-4 regulates genes involved in metabolism and neuronal development.

TFAP4 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP) to study AP-4 expression, localization, and DNA-binding activity. These antibodies typically target specific epitopes within the protein’s conserved regions (e.g., the N-terminal transactivation domain or C-terminal bHLH-ZIP domain). Validation includes testing for specificity via knockdown/knockout controls.

Commercial TFAP4 antibodies are available in monoclonal and polyclonal formats, often accompanied by validation data in peer-reviewed studies. Researchers rely on these reagents to explore AP-4’s role in disease mechanisms, therapeutic targeting, and biomarker discovery.

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