SAP30BP抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HUVEC cell lysate, Primary antibody: P10364(SAP30BP Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10364(SAP30BP Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The SAP30BP (SAP30-binding protein) antibody is a valuable tool for studying the role of SAP30BP in transcriptional regulation and chromatin remodeling. SAP30BP, also known as SANTA, is a conserved nuclear protein that interacts with SAP30. a component of the Sin3A/histone deacetylase (HDAC) corepressor complex. This complex plays a critical role in gene silencing by recruiting HDACs to modify histones, leading to chromatin condensation and transcriptional repression. SAP30BP is implicated in mediating interactions between the Sin3A/HDAC complex and other regulatory proteins, influencing processes like cell cycle control, apoptosis, and differentiation. Dysregulation of SAP30BP has been linked to cancers and neurological disorders, highlighting its biological significance.

The SAP30BP antibody is commonly used in applications such as Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous SAP30BP expression in various cell types and tissues. It aids in elucidating SAP30BP's subcellular localization, protein-protein interactions, and involvement in epigenetic mechanisms. Researchers rely on this antibody to explore its role in disease pathways and potential therapeutic targets. Validated for specificity and sensitivity, it supports studies in cancer biology, neurobiology, and epigenetics, making it essential for dissecting SAP30BP-associated molecular networks.