HORMAD2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10363(HORMAD2 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10363(HORMAD2 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The HORMAD2 antibody is a research tool designed to detect HORMAD2 (HORMA Domain-Containing Protein 2), a member of the conserved HORMA protein family involved in meiosis and genome stability. HORMAD2 is predominantly expressed in germ cells, playing critical roles in meiotic recombination, synapsis regulation, and DNA repair during gametogenesis. Unlike its paralog HORMAD1. HORMAD2 exhibits broader expression in certain somatic tissues, where its dysregulation has been linked to cancer pathogenesis, particularly in lung, breast, and ovarian cancers. Studies suggest HORMAD2 overexpression in tumors may promote genomic instability, chemotherapy resistance, and immune evasion, making it a potential therapeutic target or biomarker.

The HORMAD2 antibody, typically generated in rabbits or mice using immunogenic peptide sequences, enables the identification and localization of HORMAD2 in cells or tissues via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity is validated through knockout controls and cross-reactivity assessments with related HORMA proteins. Researchers utilize this antibody to investigate HORMAD2's dual roles: in reproductive biology (e.g., infertility studies) and oncology (e.g., tumor progression mechanisms). Recent applications also explore its interaction with meiotic proteins (e.g., SYCP3) and involvement in cancer-specific pathways like homologous recombination repair. Validation in clinical samples underscores its utility in both basic research and translational studies.