PLA2G15抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10355(PLA2G15 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P10355(PLA2G15 Antibody) at dilution 1/65. (Original magnification: ×200)    

  
  

Phospholipase A2 group XV (PLA2G15), also known as Group XV secreted phospholipase A2 (GXV sPLA2), is an enzyme encoded by the *PLA2G15* gene. It belongs to the phospholipase A2 superfamily, which hydrolyzes phospholipids to generate fatty acids and lysophospholipids, playing critical roles in lipid metabolism, membrane remodeling, and cellular signaling. PLA2G15 is distinct from other sPLA2 isoforms due to its unique substrate preference for phosphatidylcholine and its association with lipoproteins. It is implicated in lipid homeostasis, inflammation, and host defense mechanisms. Dysregulation of PLA2G15 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, making it a subject of interest in biomedical research.

Antibodies targeting PLA2G15 are essential tools for studying its expression, localization, and function. These antibodies, often developed in rabbit or mouse models, enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is validated using knockout controls or recombinant protein assays. PLA2G15 antibodies aid in exploring its role in lipid signaling pathways, disease mechanisms, and potential therapeutic targeting. Recent studies also highlight its interaction with viral envelopes, suggesting relevance in infectious disease contexts. As research advances, PLA2G15 antibodies remain vital for unraveling its multifaceted biological contributions.