KCTD4抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10343(KCTD4 Antibody) at dilution 1/135. (Original magnification: ×200)    

  
  

The KCTD4 (Potassium Channel Tetramerization Domain-Containing Protein 4) antibody is a research tool designed to detect and study the KCTD4 protein, a member of the KCTD family involved in diverse cellular processes. KCTD4 is implicated in regulating neuronal signaling and synaptic plasticity, primarily through interactions with cullin3 to form E3 ubiquitin ligase complexes, which mediate protein ubiquitination and degradation. It is enriched in the brain, particularly in regions like the hippocampus and cerebral cortex, suggesting roles in neurodevelopment and cognitive function. Dysregulation of KCTD4 has been linked to neurological disorders, including schizophrenia and intellectual disability.

Antibodies targeting KCTD4 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These studies help clarify its physiological roles, such as modulating potassium channel activity or synaptic protein turnover, and its pathological contributions to diseases. Commercial KCTD4 antibodies are typically validated for specificity in model organisms (e.g., human, mouse) and are critical for exploring molecular mechanisms in neural circuits or disease models. Ongoing research aims to define its exact biological functions and therapeutic potential in neuropsychiatric conditions.