STX6抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-5: SKOV3 cell, NIH/3T3 cell, Mouse brain tissue, Hela and 293T cell lysates, Primary antibody: P10335(STX6 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10335(STX6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10335(STX6 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

STX6 antibodies target Syntaxin 6. a protein belonging to the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, which plays a critical role in intracellular membrane trafficking. Syntaxin 6 is primarily localized to the trans-Golgi network (TGN) and endosomes, where it mediates vesicle docking and fusion processes essential for protein sorting, lysosomal biogenesis, and receptor recycling. It interacts with other SNARE proteins like VAMP4 and syntaxin 16. forming complexes that regulate retrograde transport and maintain organelle integrity. Research on STX6 has linked it to diverse cellular functions, including insulin-regulated GLUT4 translocation in adipocytes, neurotransmitter release, and autophagy. Dysregulation of Syntaxin 6 has been implicated in diseases such as cancer, neurodegenerative disorders, and diabetes, making it a focus for therapeutic exploration.

STX6 antibodies are widely used in studies to investigate protein localization, expression levels, and functional interactions. They are employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation, often validated for specificity using knockout cell lines or siRNA-mediated depletion. Commercial STX6 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein’s N- or C-terminal regions. Recent studies also utilize these antibodies to explore STX6’s role in viral entry mechanisms (e.g., SARS-CoV-2) and its interplay with autophagy-related proteins. As membrane trafficking gains attention in disease mechanisms, STX6 antibodies remain vital tools for unraveling cellular transport pathways and their pathological disruptions.