PPM1M抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 293T cell lysates, Primary antibody: P12936(B3GNT3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12936(B3GNT3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12936(B3GNT3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The PPM1M antibody is designed to target the protein phosphatase PPM1M, also known as PP2Cδ, a member of the metal-dependent protein phosphatase (PPM) family. PPM1M is a serine/threonine phosphatase involved in regulating diverse cellular processes, including metabolism, stress responses, and cell cycle control. It functions by dephosphoryulating key signaling molecules, modulating pathways such as AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (MAPK), which are critical for energy homeostasis and apoptosis.

PPM1M has gained attention for its role in metabolic diseases, particularly diabetes and obesity. Studies indicate it influences insulin sensitivity and glucose metabolism by interacting with AMPK. Dysregulation of PPM1M is linked to pathological conditions, including cardiovascular diseases and cancer, where it may act as either a tumor suppressor or promoter depending on context.

Antibodies against PPM1M are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated antibodies help elucidate PPM1M's tissue-specific roles and post-translational modifications. Recent research also explores its potential as a therapeutic target, emphasizing the need for reliable antibody reagents.

PPM1M’s conserved catalytic domain and interaction partners highlight its evolutionary significance. However, challenges remain in distinguishing isoform-specific functions due to homology within the PPM family. Ongoing studies aim to clarify its regulatory mechanisms and disease associations using antibody-based approaches.