PREPL抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cell lysate, Primary antibody: P10324(PREPL Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10324(PREPL Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10324(PREPL Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

PREPL (Proline-rich Endopeptidase-like) is a protein encoded by the PREPL gene located on chromosome 2p21. Initially identified as a member of the prolyl oligopeptidase family, it shares structural homology with serine hydrolases but lacks catalytic activity due to amino acid substitutions in its enzymatic domain. PREPL is highly expressed in the brain, muscle, and kidney, and is implicated in vesicular trafficking, lysosomal biogenesis, and neurotransmitter regulation. It interacts with adaptor protein complexes (AP-1/AP-3) involved in intracellular cargo sorting, suggesting a role in synaptic vesicle recycling and lysosomal enzyme trafficking.

Mutations or deletions in PREPL are linked to congenital disorders such as hypotonia-cystinuria syndrome (HCS) and 22q11.2 deletion syndrome-like phenotypes. These conditions manifest with neuromuscular abnormalities, growth retardation, and metabolic disturbances, underscoring PREPL’s importance in neurodevelopment and cellular homeostasis. PREPL antibodies, developed for research and diagnostics, enable the detection of protein expression, localization, and interaction partners in tissues or cell models. They are critical tools for studying PREPL’s molecular mechanisms, disease associations, and potential therapeutic targets. However, functional redundancy with paralogs (e.g., PREP) and unclear substrate specificity necessitate cautious interpretation of antibody-based assays. Ongoing research aims to clarify PREPL’s precise roles in cellular pathways and its contribution to rare genetic syndromes.